Finley Brent L, Richter Richard O, Mowat Fionna S, Mlynarek Steve, Paustenbach Dennis J, Warmerdam John M, Sheehan Patrick J
ChemRisk, San Francisco, California, USA.
J Expo Sci Environ Epidemiol. 2007 Nov;17(7):644-55. doi: 10.1038/sj.jes.7500553. Epub 2007 May 9.
We analyzed cumulative lifetime exposure to chrysotile asbestos experienced by brake mechanics in the US during the period 1950-2000. Using Monte Carlo methods, cumulative exposures were calculated using the distribution of 8-h time-weighted average exposure concentrations for brake mechanics and the distribution of job tenure data for automobile mechanics. The median estimated cumulative exposures for these mechanics, as predicted by three probabilistic models, ranged from 0.16 to 0.41 fibers per cubic centimeter (f/cm(3)) year for facilities with no dust-control procedures (1970s), and from 0.010 to 0.012 f/cm(3) year for those employing engineering controls (1980s). Upper-bound (95%) estimates for the 1970s and 1980s were 1.96 to 2.79 and 0.07-0.10 f/cm(3) year, respectively. These estimates for US brake mechanics are consistent with, but generally slightly lower than, those reported for European mechanics. The values are all substantially lower than the cumulative exposure of 4.5 f/cm(3) year associated with occupational exposure to 0.1 f/cm(3) of asbestos for 45 years that is currently permitted under the current occupational exposure limits in the US. Cumulative exposures were usually about 100- to 1,000-fold less than those of other occupational groups with asbestos exposure for similar time periods. The cumulative lifetime exposure estimates presented here, combined with the negative epidemiology data for brake mechanics, could be used to refine the risk assessments for chrysotile-exposed populations.
我们分析了1950年至2000年期间美国刹车修理工接触温石棉的累积终生暴露情况。使用蒙特卡洛方法,根据刹车修理工8小时时间加权平均暴露浓度的分布以及汽车修理工工作年限数据的分布来计算累积暴露量。由三种概率模型预测,对于没有粉尘控制程序的设施(20世纪70年代),这些修理工的估计累积暴露量中位数为每立方厘米0.16至0.41纤维(f/cm³)年,而对于采用工程控制措施的设施(20世纪80年代),该数值为每立方厘米0.010至0.012纤维年。20世纪70年代和80年代的上限(95%)估计值分别为每立方厘米1.96至2.79纤维年和每立方厘米0.07至0.10纤维年。美国刹车修理工的这些估计值与欧洲修理工报告的数值一致,但通常略低。这些数值均远低于目前美国职业暴露限值下与45年职业接触每立方厘米0.1纤维石棉相关的4.5纤维/立方厘米年的累积暴露量。累积暴露量通常比其他在相似时间段接触石棉的职业群体少约100至1000倍。此处给出的累积终生暴露估计值,结合刹车修理工的负面流行病学数据,可用于完善温石棉暴露人群的风险评估。