胎盘缺血与可溶性fms样酪氨酸激酶1：子痫前期的病因还是后果？
Placental ischemia and soluble fms-like tyrosine kinase 1: cause or consequence of preeclampsia?
作者信息
Karumanchi S A, Epstein F H
机构信息
Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA.
出版信息
Kidney Int. 2007 May;71(10):959-61. doi: 10.1038/sj.ki.5002281.
Elevated circulating soluble fms-like tyrosine kinase 1 (sFLT-1) is associated with the development of the clinical signs and symptoms of preeclampsia. Placental ischemia has been suggested as one of the etiological factors that mediate increased sFLT-1 production in patients with preeclampsia, but definitive evidence for this hypothesis was lacking. Makris et al. demonstrate that inducing placental ischemia in primates is sufficient to induce sFLT-1 upregulation and the clinical signs and symptoms of preeclampsia.
循环中可溶性fms样酪氨酸激酶1（sFLT-1）水平升高与子痫前期临床症状和体征的发展相关。胎盘缺血被认为是介导子痫前期患者sFLT-1产生增加的病因之一，但这一假说缺乏确凿证据。马克里斯等人证明，在灵长类动物中诱导胎盘缺血足以诱导sFLT-1上调以及子痫前期的临床症状和体征。
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