在淋病奈瑟菌中，两个ABC转运蛋白操纵子和抗微生物耐药基因mtrF对pilT有反应。
Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae.
作者信息
Friedrich Alexandra, Arvidson Cindy G, Shafer William M, Lee Eun-Hee, So Magdalene
机构信息
Department of Molecular Microbiology and Immunology, L220, Oregon Health Sciences University, Portland, Oregon 97201-3098, USA.
出版信息
J Bacteriol. 2007 Jul;189(14):5399-402. doi: 10.1128/JB.00300-07. Epub 2007 May 11.
Abstract
Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF.
摘要
IV型菌毛的收缩由PilT介导。我们发现，在淋病奈瑟菌MS11中，pilT功能丧失会导致mtrF（多重可转移耐药性）以及两个编码假定ABC转运蛋白的操纵子上调。这种效应是通过转录调节因子FarR间接发生的，迄今为止，FarR仅被证明可调节farAB。L-谷氨酰胺可以逆转pilT对ABC转运蛋白操纵子和mtrF的下调作用。
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