肠出血性大肠杆菌中QseA以及GrlR/GrlA对肠上皮细胞脱落基因位点的调控
QseA and GrlR/GrlA regulation of the locus of enterocyte effacement genes in enterohemorrhagic Escherichia coli.
作者信息
Russell Regan M, Sharp Faith C, Rasko David A, Sperandio Vanessa
机构信息
University of Texas Southwestern Medical Center, Department of Microbiology, Dallas, TX 75390-9048, USA.
出版信息
J Bacteriol. 2007 Jul;189(14):5387-92. doi: 10.1128/JB.00553-07. Epub 2007 May 11.
Abstract
Transcription of the locus of enterocyte effacement (LEE) genes in enterohemorrhagic Escherichia coli (EHEC) is regulated by the LEE-encoded Ler and GrlR/GrlA proteins as well as the non-LEE-encoded regulator QseA. This work demonstrates that GrlR/GrlA activate LEE2 transcription in a Ler-independent fashion, whereas transcription of grlRA is activated by QseA in both Ler-dependent and -independent manners.
摘要
肠出血性大肠杆菌（EHEC）中肠上皮细胞脱落位点（LEE）基因的转录受LEE编码的Ler和GrlR/GrlA蛋白以及非LEE编码的调节因子QseA调控。这项研究表明，GrlR/GrlA以不依赖Ler的方式激活LEE2转录，而grlRA的转录则由QseA以依赖和不依赖Ler的方式激活。
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