在果蝇中，突触形成和幼虫联想学习需要Neurexin-1。
Neurexin-1 is required for synapse formation and larvae associative learning in Drosophila.
作者信息
Zeng Xiankun, Sun Mingkuan, Liu Li, Chen Fading, Wei Liuchan, Xie Wei
机构信息
Department of Genetics and Developmental Biology, Genetics Research Center, Southeast University Medical School, Ministry of Education, 87 Dingjiaqiao Road, Nanjing 210009, Jiangsu Province, China.
出版信息
FEBS Lett. 2007 May 29;581(13):2509-16. doi: 10.1016/j.febslet.2007.04.068. Epub 2007 May 4.
Neurexins are highly polymorphic cell-surface adhesive molecules in neurons. In cultured mammalian cell system, they were found to be involved in synaptogenesis. Here, we report for the first time that Drosophila neurexin is required for synapse formation and associative learning in larvae. Drosophila genome encodes a single functional neurexin (CG7050; Neurexin-1 or Nrx-1), which is a homolog of vertebrate alpha-neurexin. Neurexin-1 is expressed in central nervous system and highly enriched in synaptic regions of the ventral ganglion and brain. Neurexin-1 null mutants are viable and fertile, but have shortened lifespan. The synapse number is decreased in central nervous system in Neurexin-1 null mutants. In addition, Neurexin-1 null mutants exhibit associative learning defect in larvae.
神经连接蛋白是神经元中高度多态的细胞表面黏附分子。在培养的哺乳动物细胞系统中，发现它们参与突触形成。在此，我们首次报道果蝇神经连接蛋白是幼虫突触形成和联想学习所必需的。果蝇基因组编码一种单一的功能性神经连接蛋白（CG7050；神经连接蛋白-1或Nrx-1），它是脊椎动物α-神经连接蛋白的同源物。神经连接蛋白-1在中枢神经系统中表达，并在腹神经节和脑的突触区域高度富集。神经连接蛋白-1基因敲除突变体是可存活和可育的，但寿命缩短。神经连接蛋白-1基因敲除突变体的中枢神经系统中的突触数量减少。此外，神经连接蛋白-1基因敲除突变体在幼虫中表现出联想学习缺陷。
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