Nachev Parashkev, Wydell Henrietta, O'neill Kevin, Husain Masud, Kennard Christopher
Department of Clinical Neuroscience, Imperial College London, St Dunstan's Road, London W6 8RP, UK.
Neuroimage. 2007;36 Suppl 2(3-3):T155-63. doi: 10.1016/j.neuroimage.2007.03.034. Epub 2007 Mar 31.
Although regions within the medial frontal cortex are known to be active during voluntary movements their precise role remains unclear. Here we combine functional imaging localisation with psychophysics to demonstrate a strikingly selective contralesional impairment in the ability to inhibit ongoing movement plans in a patient with a rare lesion involving the right pre-supplementary motor area (pre-SMA), but sparing the supplementary motor area (SMA). We find no corresponding delay in simple reaction times, and show that the inhibitory deficit is sensitive to the presence of competition between responses. The findings demonstrate that the pre-SMA plays a critical role in exerting control over voluntary actions in situations of response conflict. We discuss these findings in the context of a unified framework of pre-SMA function, and explore the degree to which extant data on this region can be explained by this function alone.
虽然已知内侧额叶皮质内的区域在自主运动期间会活跃，但其确切作用仍不清楚。在此，我们将功能成像定位与心理物理学相结合，以证明一名患有罕见病变的患者在抑制正在进行的运动计划的能力方面存在明显的对侧损伤，该病变累及右侧辅助运动前区（pre-SMA），但未累及辅助运动区（SMA）。我们发现简单反应时间没有相应延迟，并表明抑制缺陷对反应之间竞争的存在敏感。这些发现表明，在反应冲突的情况下，辅助运动前区在对自主行动施加控制方面起着关键作用。我们在辅助运动前区功能的统一框架背景下讨论这些发现，并探讨仅以此功能能否解释该区域现有数据的程度。
