紧密连接在细胞增殖和癌症中的作用。

Role of tight junctions in cell proliferation and cancer.

作者信息

González-Mariscal Lorenza, Lechuga Susana, Garay Erika

机构信息

Center for Research and Advanced Studies (Cinvestav), Department of Physiology, Biophysics and Neuroscience, Ave. Instituto Politécnico Nacional 2508, México, DF 07360, México.

出版信息

Prog Histochem Cytochem. 2007;42(1):1-57. doi: 10.1016/j.proghi.2007.01.001. Epub 2007 Feb 27.

DOI:10.1016/j.proghi.2007.01.001

PMID:17502225

Abstract

The acquisition of a cancerous phenotype by epithelial cells involves the disruption of intercellular adhesions. The reorganization of the E-cadherin/beta-catenin complex in adherens junctions during cell transformation is widely recognized. Instead the implication of tight junctions (TJs) in this process is starting to be unraveled. The aim of this article is to review the role of TJ proteins in cell proliferation and cancer.

摘要

上皮细胞获得癌性表型涉及细胞间黏附的破坏。细胞转化过程中黏着连接中E-钙黏蛋白/β-连环蛋白复合物的重组已得到广泛认可。相反，紧密连接（TJ）在此过程中的作用正开始被揭示。本文的目的是综述TJ蛋白在细胞增殖和癌症中的作用。