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产生杀白细胞素的泛耐药性金黄色葡萄球菌导致坏死性肺炎

[Panton-Valentine leukocidin-producing Staphylococcus aureus responsible for necrotizing pneumonia].

作者信息

Dubrous P, Cuguillère A, Gendrot A, Koeck J-L

机构信息

Service de biologie, HIA Robert Picque, Bordeaux, France.

出版信息

Ann Biol Clin (Paris). 2007 May-Jun;65(3):277-81.

Abstract

Panton-Valentine leukocidin-producing (PVL) Staphylococcus aureus is responsible for a highly lethal necrotizing pneumonia, which occurs predominantly in young immunocompetent patients. Hemoptysis and leucopenia often occur but are not always present. Detection of PVL gene on S. aureus strains responsible for pneumonia should help us to a better understanding of this disease, to improve its treatment with antibiotics capable of lower the toxin production and to prevent its diffusion to others persons by detection and elimination of a nasal S. aureus carriage.

摘要

产生杀白细胞素的泛耐药金黄色葡萄球菌(PVL)可导致一种高度致命的坏死性肺炎,主要发生在免疫功能正常的年轻患者中。咯血和白细胞减少经常出现,但并非总是存在。检测引起肺炎的金黄色葡萄球菌菌株上的PVL基因应有助于我们更好地了解这种疾病,通过使用能够降低毒素产生的抗生素来改善其治疗,并通过检测和消除鼻腔携带的金黄色葡萄球菌来防止其传播给其他人。

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