Young Casey Corinna, Greenberg Melanie A, Nicassio Perry M, Harpin R Edward, Hubbard David
Department of Psychiatry, University of California, San Diego, School of Medicine, La Jolla, CA, USA.
Pain. 2008 Jan;134(1-2):69-79. doi: 10.1016/j.pain.2007.03.032. Epub 2007 May 15.
This study evaluated a theoretically and empirically based model of the progression of acute neck and back pain to chronic pain and disability, developed from the literature in chronic pain, cognition, and stress and trauma. Clinical information and standardized psychosocial measures of cumulative traumatic events exposure (TLEQ), depressed mood (CES-D), pain (DDS), physical disability (PDI), and pain beliefs (PBPI) were collected at baseline from 84 acute back pain patients followed at an Acute Back Clinic over 3 months. Path analysis was used for the longitudinal prediction of perceived pain and disability. The predictive model accounted for 26% of the variance in persistent pain intensity and 58% of the variance in perceived physical disability at 3 months. Greater exposure to past traumatic life events and depressed mood were most predictive of chronic pain; depressed mood and negative pain beliefs were most predictive of chronic disability. More cumulative traumatic life events, higher levels of depression in the early stages of a new pain episode, and early beliefs that pain may be permanent significantly contribute to increased severity of subsequent pain and disability. Replication in a larger sample is desirable to confirm these paths. Early detection of elevated depressive symptoms and high trauma exposure may identify individuals at greater risk for developing chronic pain syndromes who may benefit from early multidisciplinary intervention.
本研究评估了一个基于理论和实证的急性颈肩腰背痛发展为慢性疼痛和残疾的模型,该模型是根据慢性疼痛、认知、压力与创伤方面的文献建立的。在一家急性腰痛诊所对84名急性腰痛患者进行了为期3个月的随访,在基线时收集了临床信息以及累积创伤事件暴露(创伤生活事件问卷,TLEQ)、抑郁情绪(流调中心用抑郁量表,CES-D)、疼痛(数字疼痛量表,DDS)、身体残疾(身体残疾指数,PDI)和疼痛信念(疼痛信念与感知问卷,PBPI)的标准化心理社会测量指标。采用路径分析对感知疼痛和残疾进行纵向预测。该预测模型解释了3个月时持续疼痛强度方差的26%以及感知身体残疾方差的58%。既往创伤性生活事件暴露程度越高和抑郁情绪越严重,对慢性疼痛的预测性最强;抑郁情绪和消极疼痛信念对慢性残疾的预测性最强。更多的累积创伤性生活事件、新疼痛发作早期较高的抑郁水平以及认为疼痛可能会持续存在的早期信念,均显著导致后续疼痛和残疾的严重程度增加。需要在更大样本中进行重复研究以证实这些路径。早期发现抑郁症状加重和高创伤暴露情况,可能会识别出发生慢性疼痛综合征风险更高的个体,这些个体可能会从早期多学科干预中获益。