Tielliu I F J, Verhoeven E L G, Zeebregts C J, Prins T R, Bos W T G J, Van den Dungen J J A M
Department of Surgery, University Medical Center Groningen,Groningen, The Netherlands.
J Cardiovasc Surg (Torino). 2007 Jun;48(3):275-9.
Feasibility of endovascular repair of popliteal artery aneurysms has been established. The results of this technique and the effect of the learning curve on the occurrence of complications were evaluated in a prospective cohort.
Between June 1998 and February 2007, 73 popliteal aneurysms were treated by endovascular means. Primary outcome was stent-graft patency. Secondary outcome was a combined end-point of stent-graft related complications, including occlusion, migration, stent-graft fracture, and stenosis. To study the learning curve, the cohort of patients was divided into 2 groups (group A from 1 to 23; group B from 24 to 73). Cut-off point chosen was the introduction of the more aggressive postoperative anticoagulation protocol with clopidogrel.
Eighteen (25%) stent-grafts occluded. This resulted in a reintervention in 11 patients. Migration, fracture, and stenosis were diagnosed in 9, 3 (2 leading to occlusion), and 2 limbs, respectively; these 14 complications accounted for reinterventions in 8 additional patients. In total, 19 of the 73 limbs (26%) required 20 reinterventions. Overall 3-and 5-year patency rates were 77% and 70% for primary patency, and 86% and 76% for secondary patency, respectively. There were more occlusions in group A (8/23, 35%) versus group B (10/50, 20%) (P= 0.22). With regard to the combined endpoint, there were more events in group A (14/23, 61%) than in group B (16/50, 32%) (P= 0.016).
Results of endovascular repair of popliteal artery aneurysms are improving and in range with those of open repair.
已证实腘动脉瘤血管腔内修复术的可行性。在一个前瞻性队列研究中评估了该技术的结果以及学习曲线对并发症发生情况的影响。
1998年6月至2007年2月期间,采用血管腔内方法治疗了73例腘动脉瘤。主要结局指标是支架移植物通畅情况。次要结局指标是支架移植物相关并发症的综合终点,包括闭塞、移位、支架移植物断裂和狭窄。为研究学习曲线,将患者队列分为两组(A组1至23例;B组24至73例)。选择的分界点是引入更积极的术后使用氯吡格雷抗凝方案。
18例(25%)支架移植物发生闭塞。这导致11例患者需要再次干预。分别在9例、3例(其中2例导致闭塞)和2例肢体中诊断出移位、断裂和狭窄;这14例并发症导致另外8例患者需要再次干预。73例肢体中共有19例(26%)需要20次再次干预。总体而言,3年和5年的初次通畅率分别为77%和70%,二次通畅率分别为86%和76%。A组的闭塞情况(8/23,35%)多于B组(10/50,20%)(P = 0.22)。关于综合终点,A组的事件(14/23,61%)多于B组(16/50,32%)(P = 0.016)。
腘动脉瘤血管腔内修复术的结果正在改善,与开放修复术的结果相当。