血脂异常中的线粒体能量代谢与氧化还原状态

Mitochondrial energy metabolism and redox state in dyslipidemias.

作者信息

Vercesi Anibal E, Castilho Roger F, Kowaltowski Alicia J, Oliveira Helena C F

机构信息

Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil.

出版信息

IUBMB Life. 2007 Apr-May;59(4-5):263-8. doi: 10.1080/15216540601178091.

DOI:10.1080/15216540601178091

PMID:17505963

Abstract

Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K(+) and Ca(2+) transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition.

摘要

线粒体功能的改变与代谢性疾病密切相关。在此，我们综述了有关高胆固醇血症和高甘油三酯血症中线粒体能量代谢、离子转运和氧化还原状态改变的最新证据。我们主要关注线粒体呼吸、K(+)和Ca(2+)转运、活性氧生成以及线粒体通透性转换易感性的变化。