Sheleg Sergey V, Peloponese Jean-Marie, Chi Ya-Hui, Li Yan, Eckhaus Michael, Jeang Kuan-Teh
Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
J Virol. 2007 Aug;81(15):7894-901. doi: 10.1128/JVI.00555-07. Epub 2007 May 16.
Aneuploidy is frequent in cancers. Recently it was found that pituitary tumor transforming gene (PTTG; also called Pds1p or securin) is overexpressed in many different tumors. Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus that primarily infects CD4+ T lymphocytes and causes adult T-cell leukemia. Here, we report that overexpression of human PTTG cooperated with the HTLV-I Tax oncoprotein in cellular transformation. Coexpression of Tax and PTTG enhanced chromosomal instability and neoplastic changes to levels greater than overexpression of either factor singularly. Cells that overexpressed both PTTG and Tax induced tumors more robustly in nude mice than cells that expressed either PTTG alone or Tax alone.
非整倍体在癌症中很常见。最近发现垂体肿瘤转化基因（PTTG；也称为Pds1p或分离酶）在许多不同肿瘤中过度表达。1型人类T细胞白血病病毒（HTLV-1）是一种逆转录病毒，主要感染CD4+T淋巴细胞并导致成人T细胞白血病。在此，我们报告人类PTTG的过度表达与HTLV-I Tax癌蛋白在细胞转化中协同作用。Tax和PTTG的共表达增强了染色体不稳定性和肿瘤性变化，其程度大于单独过度表达任何一种因子。同时过度表达PTTG和Tax的细胞在裸鼠中比单独表达PTTG或Tax的细胞更有力地诱导肿瘤形成。
