蜗牛、斑马和bHLH因子在肿瘤进展中的作用：对抗上皮表型的联盟？
Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
作者信息
Peinado Héctor, Olmeda David, Cano Amparo
机构信息
Departamento de Bioquímica, Facultad de Medicina, Universidad Autónoma de Madrid (UAM), Instituto de Investigaciones Biomédicas Alberto Sols CSIC-UAM, Arturo Duperier 4, 28029 Madrid, Spain.
出版信息
Nat Rev Cancer. 2007 Jun;7(6):415-28. doi: 10.1038/nrc2131. Epub 2007 May 17.
The molecular mechanisms that underlie tumour progression are still poorly understood, but recently our knowledge of particular aspects of some of these processes has increased. Specifically, the identification of Snail, ZEB and some basic helix-loop-helix (bHLH) factors as inducers of epithelial-mesenchymal transition (EMT) and potent repressors of E-cadherin expression has opened new avenues of research with potential clinical implications.
肿瘤进展背后的分子机制仍未被充分理解，但最近我们对其中一些过程特定方面的认识有所增加。具体而言，将Snail、ZEB和一些碱性螺旋-环-螺旋（bHLH）因子鉴定为上皮-间质转化（EMT）的诱导剂和E-钙黏蛋白表达的强效抑制剂，为具有潜在临床意义的新研究途径打开了大门。
Zotero 插件