当安慰剂并非“安慰剂”：安慰剂对餐后血糖的影响

When a placebo is not a 'placebo': a placebo effect on postprandial glycaemia.

作者信息

Sievenpiper John L, Ezatagha Adish, Dascalu Anamaria, Vuksan Vladimir

机构信息

Risk Factor Modification Centre, St Michael's Hospital and Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

出版信息

Br J Clin Pharmacol. 2007 Oct;64(4):546-9. doi: 10.1111/j.1365-2125.2007.02929.x. Epub 2007 May 17.

DOI:10.1111/j.1365-2125.2007.02929.x

PMID:17509038

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2048544/

Abstract

AIMS

Placebo effects in clinical trials remain uncertain. To investigate a placebo effect on acute postprandial plasma glucose, we conducted a follow-up investigation on a previous study.

METHODS

The effect of placebo (9 g encapsulated cornstarch +500 ml water, taken at -40 min) on the plasma glucose response to a 75-g oral glucose tolerance test (OGTT) was assessed in a previous study in 12 healthy subjects (gender, five male, seven female; age 27 +/- 6 years; body mass index 24 +/- 3.4 kg m(-2)). This was compared with the effect of a water control (500 ml water taken alone at -40 min) on the same outcome in the same subjects in a follow-up study.

RESULTS

Cornstarch placebo decreased plasma glucose area under the curve during the 75-g OGTT by 28% [Delta (95% confidence interval) -63.3 min mmol(-1) l(-1) (-218.33, 91.66), P < 0.02] compared with the water control (P < 0.05).

CONCLUSIONS

Postprandial plasma glucose outcomes may be vulnerable to placebo effects.

摘要

目的

临床试验中的安慰剂效应仍不明确。为研究安慰剂对急性餐后血糖的影响，我们对之前的一项研究进行了随访调查。

方法

在之前一项研究中，对12名健康受试者（性别：5名男性，7名女性；年龄27±6岁；体重指数24±3.4 kg m⁻²）评估了安慰剂（9克胶囊装玉米淀粉+500毫升水，在-40分钟时服用）对75克口服葡萄糖耐量试验（OGTT）的血糖反应的影响。在一项随访研究中，将其与水对照（仅在-40分钟时服用500毫升水）对相同受试者相同结果的影响进行比较。