Fajdic J, Bukovic D, Hrgovic Z, Habek M, Gugic D, Jonas D, Fassbender Walter J
General Hospital, Pozega, Croatia.
Eur J Med Res. 2007 Apr 26;12(4):169-72.
Fournier's gangrene is a rare infection characterized with fast-progressing myonecrosis, that affect regions of perineum, genitalia and perianal area. This retrospective study presents authors' experiences and their principles in early diagnosis and treatment of Fournier's gangrene. The goal of this paper is to point out numerous diagnostically and therapeutic difficulties that lead to a high mortality if not recognized in time. We here describe seven male patients with myonecrosis and necrotising fasciitis in scrotal, perianal and perineal regions. Average age was 61 years (form 57 to 66 years of age), and average length of treatment was 25.8 days (from 14 to 36 days), with lethality of 14% (one case). We have recognised diabetes mellitus as risk factor, together with urethrostenosis, and other diseases of the perianal region (hemorrhoids, anal fissure, abscesses). Our hypothesis is that the key of the successful treatment is to treat as soon as symptoms onset, early and aggressive necrectomy under broad antibiotic protection. We also emphasize the possibility of recurrence of this disease even several years after treatment.
福尼尔坏疽是一种罕见的感染,其特征为进展迅速的肌坏死,累及会阴、生殖器和肛周区域。这项回顾性研究介绍了作者在福尼尔坏疽早期诊断和治疗方面的经验及原则。本文的目的是指出众多诊断和治疗上的困难,若不及时识别,这些困难会导致高死亡率。我们在此描述了7例阴囊、肛周和会阴区域发生肌坏死和坏死性筋膜炎的男性患者。平均年龄为61岁(57至66岁),平均治疗时长为25.8天(14至36天),致死率为14%(1例)。我们已确认糖尿病为风险因素,还有尿道狭窄以及其他肛周疾病(痔疮、肛裂、脓肿)。我们的假设是,成功治疗的关键在于症状一出现就进行治疗,在广泛的抗生素保护下尽早积极地进行坏死组织切除术。我们还强调了即便在治疗数年之后该病仍有复发的可能性。