Suzuki Osamu, Abe Masafumi
First Department of Pathology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
J Clin Exp Hematop. 2007 Apr;47(1):19-21. doi: 10.3960/jslrt.47.19.
Sea-blue histiocytosis is a rare disorder seen in patients with lipid metabolic or ceroid storage diseases. Sea-blue histiocytes are ceroid-laden macrophages detectable by May-Giemsa staining. We report a case of a 28-year-old woman diagnosed with Niemann-Pick disease at 2 or 3 years of age. To confirm this diagnosis, we examined her bone marrow, which revealed scattered foci containing aggregates of foamy macrophages. May-Giemsa staining identified blue-staining foamy macrophages, referred to as sea-blue histiocytes. In summary, we report the detection of sea-blue histiocytosis in an adult with Niemann-Pick disease.
海蓝色组织细胞增生症是一种罕见的疾病，见于脂质代谢或类蜡质贮积病患者。海蓝色组织细胞是经美吉姆萨染色可检测到的含类蜡质的巨噬细胞。我们报告一例28岁女性病例，该患者在2或3岁时被诊断为尼曼-匹克病。为证实这一诊断，我们检查了她的骨髓，发现有散在病灶，其中含有泡沫状巨噬细胞聚集物。美吉姆萨染色鉴定出蓝色染色的泡沫状巨噬细胞，即海蓝色组织细胞。总之，我们报告了在一名成年尼曼-匹克病患者中检测到海蓝色组织细胞增生症。
