无抗凝剂情况下水母瓣膜的血液相容性。

Blood compatibility of the jellyfish valve without anticoagulant.

作者信息

Imachi K, Mabuchi K, Chinzei T, Abe Y, Imanishi K, Suzukawa M, Yonezawa T, Kouno A, Ono T, Nozawa H

机构信息

Institute of Medical Electronics, Faculty of Medicine, University of Tokyo, Japan.

出版信息

ASAIO Trans. 1991 Jul-Sep;37(3):M220-2.

PMID:1751119

Abstract

The blood compatibility of the jellyfish valve was studied. Artificial heart (AH) blood pumps incorporating jellyfish valves were connected to 18 goats as total artificial hearts (TAHs) and pumped for 1 to 125 days without anticoagulant or antiplatelet drugs. No thrombus was formed on the valve membrane or around the valve seat. Scanning electron microscopy showed almost no platelet deposition or microfibrin clot formation on the valve membrane, including its central region; the spokes of the valve seat were also free from platelet and microfibrin clots. No calcification was observed during these tests, and plasma free hemoglobin was between 2 and 7 mg/dl. The jellyfish valve revealed good blood compatibility, even without anticoagulant use.

摘要

研究了水母瓣膜的血液相容性。将装有水母瓣膜的人工心脏（AH）血泵作为全人工心脏（TAH）连接到18只山羊身上，并在不使用抗凝剂或抗血小板药物的情况下泵血1至125天。瓣膜膜或瓣膜座周围未形成血栓。扫描电子显微镜显示，瓣膜膜（包括其中心区域）上几乎没有血小板沉积或微纤维蛋白凝块形成；瓣膜座的辐条也没有血小板和微纤维蛋白凝块。在这些测试中未观察到钙化，血浆游离血红蛋白在2至7mg/dl之间。即使不使用抗凝剂，水母瓣膜也显示出良好的血液相容性。