Waber Deborah P, De Moor Carl, Forbes Peter W, Almli C Robert, Botteron Kelly N, Leonard Gabriel, Milovan Denise, Paus Tomas, Rumsey Judith
Department of Psychiatry, Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
J Int Neuropsychol Soc. 2007 Sep;13(5):729-46. doi: 10.1017/S1355617707070841. Epub 2007 May 18.
The National Institutes of Health (NIH) Magnetic Resonance Imaging (MRI) Study of Normal Brain Development is a landmark study in which structural and metabolic brain development and behavior are followed longitudinally from birth to young adulthood in a population-based sample of healthy children. The neuropsychological assessment protocol for children aged 6 to 18 years is described and normative data are presented for participants in that age range (N = 385). For many measures, raw score performance improved steeply from 6 to 10 years, decelerating during adolescence. Sex differences were documented for Block Design (male advantage), CVLT, Pegboard and Coding (female advantage). Household income predicted IQ and achievement, as well as externalizing problems and social competence, but not the other cognitive or behavioral measures. Performance of this healthy sample was generally better than published norms. This linked imaging-clinical/behavioral database will be an invaluable public resource for researchers for many years to come.
美国国立卫生研究院（NIH）的正常脑发育磁共振成像（MRI）研究是一项具有里程碑意义的研究，该研究在一个基于人群的健康儿童样本中，对从出生到青年期的脑结构和代谢发育以及行为进行了纵向跟踪。本文描述了6至18岁儿童的神经心理学评估方案，并给出了该年龄范围内参与者的常模数据（N = 385）。对于许多测量指标，原始分数表现从6岁到10岁急剧提高，在青春期减缓。在积木设计（男性优势）、加利福尼亚语言学习测验（CVLT）、钉板测试和译码测试（女性优势）方面记录到了性别差异。家庭收入预测了智商和学业成绩，以及外化问题和社会能力，但不能预测其他认知或行为指标。这个健康样本的表现总体上优于已发表的常模。这个关联的影像 - 临床/行为数据库在未来许多年将是研究人员极其宝贵的公共资源。
