Siroux V, Oryszczyn M P, Varraso R, Le Moual N, Bousquet J, Charpin D, Gormand F, Kennedy S, Maccario J, Pison C, Rage E, Scheinmann P, Vervloet D, Pin I, Kauffmann F
Inserm, U823, Institut Albert Bonniot, Grenoble, France.
Rev Mal Respir. 2007 May;24(5):599-608. doi: 10.1016/s0761-8425(07)91127-4.
EGEA (Epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), a case control and family study including 2048 individuals, was initiated to look for environmental and genetic risk factors for asthma. A synthesis of the results obtained since 2002 on phenotypic and environmental aspects of asthma severity and allergy are presented in this article.
The results support a role for hormonal factors in asthma severity and in various allergic markers of asthma. A greater body mass index was related to a more severe asthma in women with early menarche. Associations between markers of allergy (eosinophils, IgE and atopy) and hormonal dependent events in women (premenstrual asthma, menopause and oral contraceptive use) have been found. In asthmatics, exposure to agents known to be associated with occupational asthma, active and passive smoking were associated with an increased clinical asthma severity score. The study underlines the protective role of country living and exposure to pets in early life on allergy markers in adulthood, supporting the hygiene hypothesis.
New hypothesis will be tested in the near future from the second stage of this survey.
EGEA（哮喘、支气管高反应性和特应性的遗传与环境流行病学研究）是一项涵盖2048名个体的病例对照和家系研究，旨在探寻哮喘的环境和遗传风险因素。本文呈现了自2002年以来在哮喘严重程度和过敏的表型及环境方面所获结果的综合情况。
结果支持激素因素在哮喘严重程度及哮喘的各种过敏标志物中发挥作用。初潮早的女性中，较高的体重指数与更严重的哮喘相关。已发现女性过敏标志物（嗜酸性粒细胞、免疫球蛋白E和特应性）与激素相关事件（经前哮喘、绝经和口服避孕药使用）之间存在关联。在哮喘患者中，接触已知与职业性哮喘相关的因素、主动和被动吸烟与临床哮喘严重程度评分增加相关。该研究强调了乡村生活和早年接触宠物对成年期过敏标志物的保护作用，支持卫生假说。
该调查的第二阶段将在不久的将来检验新的假说。
