Weiss Wolfgang, Horninger Wolfgang, Forthuber Britta C, Ulmer Hanno, Lukas Peter, Sweeney Reinhart A
Department of Radiotherapy, University Hospital of Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria.
Strahlenther Onkol. 2007 Jun;183(6):321-6. doi: 10.1007/s00066-007-1672-7.
To evaluate survival and toxicity rates after primary external-beam radiation for the treatment of prostate cancer.
Data of 306 patients treated with conformal external beam radiation between 1996 and 2001 were collected. These were evaluated in terms of overall, cause-specific and disease-free survival as well as toxicity. Furthermore, an investigation of possible risk factors was performed.
Toxicity rates compared favorably with other series with 5.2% RTOG 1-2 and no RTOG > 2 long-term side effects. Actuarial 5-year overall survival rates with and without biochemical failure were 77% versus 78%, cancer-specific survival was 85.41% versus 100%, and disease-free survival was 71.54%, respectively. Potential risk factors for cancer-related death were biochemical failure, initial serum prostate-specific antigen (PSA) and Gleason score.
Toxicity rates were found to be surprisingly low compared to other series, which is likely due to low daily dose and consistent MR-based treatment planning. In terms of survival, no significant differences to other trials could be observed. Initial PSA and Gleason score were significant predictors for treatment outcome in terms of survival.
评估原发性外照射放疗治疗前列腺癌后的生存率和毒性率。
收集了1996年至2001年间接受适形外照射放疗的306例患者的数据。对这些数据进行了总体生存率、病因特异性生存率、无病生存率以及毒性方面的评估。此外，还对可能的风险因素进行了调查。
毒性率与其他系列相比情况良好，放射性肿瘤协作组（RTOG）1 - 2级的发生率为5.2%，且无RTOG > 2级的长期副作用。有生化失败和无生化失败情况下的精算5年总生存率分别为77%和78%，癌症特异性生存率分别为85.41%和100%，无病生存率为71.54%。癌症相关死亡的潜在风险因素为生化失败、初始血清前列腺特异性抗原（PSA）和Gleason评分。
与其他系列相比，毒性率低得出奇，这可能是由于每日剂量低以及基于磁共振成像的一致治疗计划。在生存率方面，与其他试验未观察到显著差异。初始PSA和Gleason评分是生存方面治疗结果的重要预测指标。
