Iwase H, Gunzert-Marx K, Haettner E, Schardt D, Gutermuth F, Kraemer M, Kraft G
Biophysics, GSI, Darmstadt, Germany.
Radiat Prot Dosimetry. 2007;126(1-4):615-8. doi: 10.1093/rpd/ncm140. Epub 2007 May 23.
High-energy (12)C ions offer favourable conditions for the treatment of deep-seated local tumours. Several facilities for the heavy ion therapy are planned or under construction, for example the new clinical ion-therapy unit HIT at the Radiological University Clinics in Heidelberg. In order to improve existing treatment planning models, it is essential to evaluate the secondary fragment production and to include these contributions to the therapy dose with higher accuracy. Secondary neutrons are most abundantly produced in the reactions between (12)C beams and tissues. The dose contribution to tissues by a neutron is fairly small compared with the projectile and the other charged fragments due to no ionisation and the small reaction cross-sections; however, it distributes in a considerably wider region beyond the bragg-peak because of the strong penetrability. Systematic data on energy spectra and doses of secondary neutrons produced by (12)C beams using water targets of different thicknesses for various detection angles have therefore been measured in this study at GSI Darmstadt.
高能(12)C离子为深部局部肿瘤的治疗提供了有利条件。多个重离子治疗设施正在规划或建设中,例如海德堡放射大学诊所的新型临床离子治疗装置HIT。为了改进现有的治疗计划模型,评估次级碎片的产生并更精确地将这些贡献纳入治疗剂量至关重要。次级中子在(12)C束与组织的反应中产生得最为丰富。与射弹和其他带电碎片相比,中子对组织的剂量贡献相当小,这是因为中子不产生电离且反应截面小;然而,由于其强穿透性,它在布拉格峰以外的区域分布得相当广泛。因此,本研究在达姆施塔特的GSI使用不同厚度的水靶,针对各种探测角度,测量了由(12)C束产生的次级中子的能谱和剂量的系统数据。