胚胎干细胞培养作为发育细胞生物学的一种工具。

Embryonic stem-cell culture as a tool for developmental cell biology.

作者信息

Nishikawa Shin-Ichi, Jakt Lars Martin, Era Takumi

机构信息

Laboratory of Stem Cell Research, Center for Developmental Biology, Minatojima Minamimachi 2-2-3, Chuoku, Kobe, 650-0047 Japan.

出版信息

Nat Rev Mol Cell Biol. 2007 Jun;8(6):502-7. doi: 10.1038/nrm2189.

DOI:10.1038/nrm2189

PMID:17522593

Abstract

The cell biology of the early processes of mammalian embryogenesis, such as germ-layer formation, has been technically challenging to study owing to the size and accessibility of mammalian embryos. Embryonic stem cells, which can generate the three germ layers in vitro, are useful for studying embryogenesis at the cellular level. So, how can the study of embryonic stem cells and their differentiation provide a deeper understanding of the cell biology of early development?

摘要

哺乳动物胚胎发生早期过程（如胚层形成）的细胞生物学研究，由于哺乳动物胚胎的大小和可操作性，在技术上一直具有挑战性。胚胎干细胞能够在体外生成三个胚层，对于在细胞水平研究胚胎发生很有用。那么，对胚胎干细胞及其分化的研究如何能让我们更深入地理解早期发育的细胞生物学呢？