Soya Hideaki, Nakamura Toru, Deocaris Custer C, Kimpara Akiyo, Iimura Miho, Fujikawa Takahiko, Chang Hyukki, McEwen Bruce S, Nishijima Takeshi
Laboratory of Exercise Biochemistry, University of Tsukuba Graduate School of Comprehensive Human Sciences, 1-1-1 Tennoudai, Tsukuba 305-8574, Japan.
Biochem Biophys Res Commun. 2007 Jul 13;358(4):961-7. doi: 10.1016/j.bbrc.2007.04.173. Epub 2007 May 7.
Although chronic voluntary physical activity has been shown to enhance hippocampal brain-derived neurotrophic factor (BDNF) expression in animals, the effects of forced exercise on a treadmill have not been fully investigated. We assessed induction of c-fos and BDNF expression with acute exercise at different running intensities. The mRNA for c-fos, a marker for neuronal activation, was up-regulated even under low-intensity running (15 m/min), although its induction appeared to be intensity dependent. On the other hand, increases in BDNF mRNA and protein were seen only at low-intensity running. At moderate-intensity running (25 m/min) which elevated blood lactate and corticosterone levels, induction of BDNF mRNA, but not its protein, was even depressed. Our study shows the first evidence that with an acute low-intensity exercise that is minimally stressful, hippocampal activation and BDNF expression can be achieved lending support to the idea that mild exercise could yield to greater benefits in hippocampal functions compared to the more strenuous forms.
虽然长期自主进行体育活动已被证明可增强动物海马体中脑源性神经营养因子（BDNF）的表达，但在跑步机上进行强迫运动的影响尚未得到充分研究。我们评估了不同跑步强度下急性运动对c-fos和BDNF表达的诱导作用。c-fos作为神经元激活的标志物，其mRNA即使在低强度跑步（15米/分钟）时也会上调，尽管其诱导似乎与强度有关。另一方面，仅在低强度跑步时观察到BDNF mRNA和蛋白质增加。在使血乳酸和皮质酮水平升高的中等强度跑步（25米/分钟）时，BDNF mRNA的诱导增加，但其蛋白质诱导反而受到抑制。我们的研究首次证明，通过压力最小的急性低强度运动，可以实现海马体激活和BDNF表达，这支持了与更剧烈形式的运动相比，轻度运动可能对海马体功能产生更大益处的观点。
