RhoE的过表达在非小细胞肺癌中具有预后价值。
Overexpression of RhoE has a prognostic value in non-small cell lung cancer.
作者信息
Zhang Cuiyan, Zhou Fang, Li Ning, Shi Susheng, Feng Xiaoli, Chen Zhaoli, Hang Jie, Qiu Bin, Li Baozhong, Chang Sheng, Wan Junting, Shao Kang, Xing Xuezhong, Tan Xiaogang, Wang Zhen, Xiong Meihua, He Jie
机构信息
Department of Thoracic Surgery, Peking Union Medical College, Chinese Academy of Medical Sciences, 100021, Beijing, China.
出版信息
Ann Surg Oncol. 2007 Sep;14(9):2628-35. doi: 10.1245/s10434-007-9457-x. Epub 2007 May 25.
BACKGROUND
Increasing evidence has suggested that RhoE plays an important role in carcinogenesis and progression. However, the correlation between RhoE expression and clinical outcome in lung cancer has not been investigated.
METHODS
RhoE expression was detected by immunohistochemistry on tissue microarray containing samples from 115 patients with non-small cell lung cancer with a median follow-up of 54 months.
RESULTS
RhoE was overexpressed in the cytoplasm of lung cancer cells compared with undetectable expression of RhoE in the adjacent nontumoral cells. Patients with RhoE-negative tumors had substantially longer cancer-related survival than did patients with RhoE-positive tumors. Multivariate analysis showed that RhoE overexpression was an independent marker for cancer-related survival in the entire population after adjusting for other prognostic factors.
CONCLUSIONS
RhoE expression may serve as an unfavorable prognostic factor in patients with non-small cell lung cancer.
背景
越来越多的证据表明RhoE在肿瘤发生和进展中起重要作用。然而，RhoE表达与肺癌临床预后之间的相关性尚未得到研究。
方法
通过免疫组织化学检测了来自115例非小细胞肺癌患者的组织芯片样本中的RhoE表达，中位随访时间为54个月。
结果
与相邻非肿瘤细胞中未检测到RhoE表达相比，肺癌细胞胞质中RhoE过表达。RhoE阴性肿瘤患者的癌症相关生存期明显长于RhoE阳性肿瘤患者。多变量分析显示，在调整其他预后因素后，RhoE过表达是整个人群中癌症相关生存的独立标志物。
结论
RhoE表达可能是非小细胞肺癌患者不良的预后因素。
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