Yilmaz Aygen, Bahat Elif, Yilmaz Gulsun Gulay, Hasanoglu Alev, Akman Sema, Guven Ayfer Gur
Department of Pediatric Gastroenterology, Akdeniz University, Antalya, Turkey.
Pediatr Int. 2007 Jun;49(3):310-3. doi: 10.1111/j.1442-200X.2007.02370.x.
The purpose of the present paper was to investigate the effects of vitamin A supplementation on recurrent lower urinary tract infections (RUTI).
Twenty-four patients with non-complicated RUTI were included in a placebo-controlled, double-blinded study. Twelve patients received a single dose of 200,000 IU vitamin A in addition to antimicrobial therapy. Patient and control groups (each containing 12 patients) were followed for up to 1 year and were evaluated for eradication and frequency of lower urinary tract infections (UTI). Serum levels of vitamin A and beta-carotene were determined periodically.
During the first 6 months follow-up period the infection rate of the vitamin A-supplemented group reduced from 3.58 to 0.75 per 6 months, and in the subsequent 6 months the infection rate was 1.75 per 6 months. These values were calculated as 2.75, 2.83 and 2.66, respectively, in the placebo group.
Vitamin A supplementation may have an adjuvant effect on the treatment of RUTI.
本文旨在研究补充维生素A对复发性下尿路感染（RUTI）的影响。
24例非复杂性RUTI患者纳入一项安慰剂对照、双盲研究。12例患者除接受抗菌治疗外，还接受了单剂量200,000 IU维生素A。对患者组和对照组（每组12例患者）进行长达1年的随访，并评估下尿路感染（UTI）的根除情况和发生频率。定期测定血清维生素A和β-胡萝卜素水平。
在最初6个月的随访期内，补充维生素A组的感染率从每6个月3.58次降至0.75次，在随后6个月中感染率为每6个月1.75次。安慰剂组的这些值分别计算为2.75、2.83和2.66。
补充维生素A可能对RUTI治疗有辅助作用。
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