膳食脂肪对摇头丸所致高热的影响。
Influence of dietary fats on Ecstasy-induced hyperthermia.
作者信息
Mills E M, Weaver K L, Abramson E, Pfeiffer M, Sprague J E
机构信息
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX, USA.
出版信息
Br J Pharmacol. 2007 Aug;151(7):1103-8. doi: 10.1038/sj.bjp.0707312. Epub 2007 May 29.
Abstract
BACKGROUND AND PURPOSE
Studies were designed to examine the effects of dietary fats on metabolic effects of 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). These effects included hyperthermia, expression of uncoupling protein (UCP1 and 3) in brown adipose tissue or skeletal muscle and plasma free fatty acid (FFA) levels.
EXPERIMENTAL APPROACH
Male Sprague-Dawley rats were fed either a high-fat diet (HFD, 60% kcal) or a lower fat isocaloric controlled diet (LFD, 10% kcal) for 28 days before MDMA challenge.
KEY RESULTS
No significant differences were observed between LFD and HFD groups in terms of body weight, plasma thyroxine (T4) levels and expression of brown fat UCP1 or skeletal muscle UCP3 protein. HFD significantly raised levels of circulating FFA and potentiated the thermogenesis induced by MDMA (10 mg kg(-1), s.c.), compared to the effects of the LFD. Moreover, 30 and 60 min after MDMA administration, plasma FFA levels decreased in HFD animals, but were markedly elevated in the LFD group.
CONCLUSIONS AND IMPLICATIONS
These results indicate that high-fat feeding regulates MDMA-induced thermogenesis by augmenting the activation of UCP rather than its expression.
摘要
背景与目的
开展多项研究以检验膳食脂肪对3,4-亚甲基二氧甲基苯丙胺（MDMA，摇头丸）代谢效应的影响。这些效应包括体温过高、棕色脂肪组织或骨骼肌中解偶联蛋白（UCP1和3）的表达以及血浆游离脂肪酸（FFA）水平。
实验方法
在给予MDMA刺激前28天，给雄性斯普拉格-道利大鼠喂食高脂饮食（HFD，60%千卡）或低脂等热量对照饮食（LFD，10%千卡）。
主要结果
在体重、血浆甲状腺素（T4）水平以及棕色脂肪UCP1或骨骼肌UCP3蛋白表达方面，LFD组和HFD组之间未观察到显著差异。与LFD的作用相比，HFD显著提高了循环FFA水平，并增强了MDMA（10毫克/千克，皮下注射）诱导的产热作用。此外，给予MDMA后30和60分钟，HFD组动物的血浆FFA水平下降，但LFD组则显著升高。
结论与启示
这些结果表明，高脂喂养通过增强UCP的激活而非其表达来调节MDMA诱导的产热作用。
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