Schoefberger Wolfgang, Smrecki Vilko, Vikić-Topić Drazen, Müller Norbert
Johannes Kepler University Linz, Altenbergerstrasse 69, 4040 Linz, Austria.
Magn Reson Chem. 2007 Jul;45(7):583-9. doi: 10.1002/mrc.2013.
We present a new application of covariance nuclear magnetic resonance processing based on 1H--13C-HMBC experiments which provides an effective way for establishing indirect 1H--1H and 13C--13C nuclear spin connectivity at natural isotope abundance. The method, which identifies correlated spin networks in terms of covariance between one-dimensional traces from a single decoupled HMBC experiment, derives 13C--13C as well as 1H--1H spin connectivity maps from the two-dimensional frequency domain heteronuclear long-range correlation data matrix. The potential and limitations of this novel covariance NMR application are demonstrated on two compounds: eugenyl-beta-D-glucopyranoside and an emodin-derivative.
我们展示了一种基于1H-13C-HMBC实验的协方差核磁共振处理新应用，该应用为在天然同位素丰度下建立间接的1H-1H和13C-13C核自旋连接提供了一种有效方法。该方法根据单个去耦HMBC实验的一维谱线之间的协方差来识别相关自旋网络，从二维频域异核长程相关数据矩阵中推导13C-13C以及1H-1H自旋连接图。在两种化合物：丁香酚基-β-D-吡喃葡萄糖苷和大黄素衍生物上展示了这种新型协方差核磁共振应用的潜力和局限性。
