[一例嗜酸性粒细胞增多综合征继发支气管哮喘、脑室内血栓形成和十二指肠炎症]

[A case of hypereosinophilic syndrome followed by bronchial asthma, intraventricular thrombus, and duodenitis].

作者信息

Ohtsuka Y, Doi I, Aoi K, Hiraga T, Munakata M, Kawakami Y

机构信息

First Department of Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.

出版信息

Nihon Kyobu Shikkan Gakkai Zasshi. 1991 Oct;29(10):1322-7.

PMID:1753511

Abstract

We report a 43-year-old male with hypereosinophilic syndrome. The patient has had eosinophilia since the age of 25. He developed bronchial asthma at 41 years of age. In the following year, he consulted a gastroenterologist because of fever and abdominal discomfort. Upper gastrointestinal study showed duodenitis. At the age of 43 years, there was slight fever, watery diarrhea, and eosinophilia. Examination in our department disclosed hypereosinophilic syndrome associated with duodenitis, endomyocarditis with an intraventricular thrombus, and bronchial asthma caused by house dust. Both prednisolone and aspirin were administered with improvement of eosinophilia and partial thrombolysis. Assays of IL-3, GM-CSF, and IL-5 revealed increased activity of IL-5, GM-CSF, and IL-3 in this order. Especially IL-5 has by far the strongest activity in these cytokines. IL-5 may play an important role in the development of hypereosinophilic syndrome.

摘要

我们报告一例43岁的嗜酸性粒细胞增多综合征男性患者。该患者自25岁起就出现嗜酸性粒细胞增多。他在41岁时患上支气管哮喘。次年，他因发热和腹部不适咨询了胃肠病学家。上消化道检查显示为十二指肠炎症。43岁时，他出现低热、水样腹泻和嗜酸性粒细胞增多。我院检查发现其患有与十二指肠炎症、伴有心室内血栓的心内膜炎以及由屋尘引起的支气管哮喘相关的嗜酸性粒细胞增多综合征。给予泼尼松龙和阿司匹林治疗后，嗜酸性粒细胞增多情况有所改善，且部分血栓溶解。白细胞介素-3（IL-3）、粒细胞-巨噬细胞集落刺激因子（GM-CSF）和白细胞介素-5（IL-5）检测显示，IL-5、GM-CSF和IL-3的活性依次增加。特别是IL-5在这些细胞因子中活性最强。IL-5可能在嗜酸性粒细胞增多综合征的发生发展中起重要作用。