Le Hir M, Eckardt K U, Kaissling B, Koury S T, Kurtz A
Medizinische Universitätspoliklinik, Kantonsspital Basel.
Klin Wochenschr. 1991 Sep 3;69(13):567-75. doi: 10.1007/BF01649319.
The kidney is the main site of erythropoietin (EPO) formation. Oxygen sensing in the kidney itself plays a major role in the control of EPO synthesis. By in situ hybridization it has been established that the EPO-producing cells are situated in the interstitium of the cortical labyrinth, but they have not been precisely identified. Morphological findings provide new insights into the location and mechanism of oxygen sensing in the kidney. In addition to causing an increase in the number of cells containing EPO messenger RNA, anemia provokes structural changes exclusively in the cortical labyrinth. Specifically, the fibroblasts become enlarged and show increased activity of 5'-nucleotidase, and the S1 segment of the proximal tubule shows similar alterations as in various models of hypoxia. Thus, structures that are situated in the close vicinity of the EPO-producing cells appear to be sensitive to decreased oxygen delivery.
肾脏是促红细胞生成素（EPO）形成的主要部位。肾脏自身的氧感应在EPO合成的调控中起主要作用。通过原位杂交已确定产生EPO的细胞位于皮质迷路的间质中，但尚未精确鉴定。形态学研究结果为肾脏中氧感应的位置和机制提供了新的见解。除了导致含EPO信使核糖核酸的细胞数量增加外，贫血仅在皮质迷路引起结构变化。具体而言，成纤维细胞变大并显示5'-核苷酸酶活性增加，近端小管的S1段显示出与各种缺氧模型中类似的改变。因此，位于产生EPO细胞附近的结构似乎对氧输送减少敏感。
