Becker S M, Kuznetsov A V
Mechanical and Aerospace Engineering, North Carolina State University, Box 7910, Raleigh, NC 27695, USA.
J Biomech Eng. 2007 Jun;129(3):330-40. doi: 10.1115/1.2720910.
Electroporation is an approach used to enhance transdermal transport of large molecules in which the skin is exposed to a series of electric pulses. The structure of the transport inhibiting outer layer, the stratum corneum, is temporarily destabilized due to the development of microscopic pores. Consequently agents that are ordinarily unable to pass into the skin are able to pass through this outer barrier. Of possible concern when exposing biological tissue to an electric field is thermal tissue damage associated with Joule heating. This paper shows the importance of using a composite model in calculating the electrical and thermal effects associated with skin electroporation. A three-dimensional transient finite-volume model of in vivo skin electroporation is developed to emphasize the importance of representing the skin's composite layers and to illustrate the underlying relationships between the physical parameters of the composite makeup of the skin and resulting thermal damage potential.
电穿孔是一种用于增强大分子经皮运输的方法，在该方法中皮肤会暴露于一系列电脉冲。由于微观孔隙的形成，抑制运输的外层即角质层的结构会暂时不稳定。因此，通常无法进入皮肤的药剂能够穿过这一外部屏障。将生物组织暴露于电场时，可能需要关注的是与焦耳热相关的热组织损伤。本文展示了使用复合模型计算与皮肤电穿孔相关的电效应和热效应的重要性。开发了一个体内皮肤电穿孔的三维瞬态有限体积模型，以强调表示皮肤复合层的重要性，并说明皮肤复合组成的物理参数与潜在热损伤之间的内在关系。
