福莫特罗对特应性哮喘患者变应原诱导的细胞因子合成的影响。
Effect of formoterol on allergen-induced cytokine synthesis by atopic asthmatics.
作者信息
Hashimoto Tomomi, Kitamura Noriko, Kobayashi Noriaki, Suko Matsunobu, Kaminuma Osamu, Mori Akio
机构信息
Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Sagamihara, Kanagawa, Japan.
出版信息
Int Arch Allergy Immunol. 2007;143 Suppl 1:106-9. doi: 10.1159/000101415. Epub 2007 May 1.
BACKGROUND
Effect of formoterol, long-acting beta(2 )agonists, on T cell cytokine synthesis was examined.
METHODS
Human peripheral blood mononuclear cells were obtained from atopic asthmatics, and stimulated with Dermatophagoidesfarinae extract. Various concentrations of formoterol were added from the start of some cultures. Cytokine production and cell proliferation were analyzed.
RESULTS
Allergen-induced IL-5, IL-13, and IFN-gamma production of PBMC were significantly suppressed by formoterol in a dose-dependent manner, whereas the proliferation response was not suppressed.
CONCLUSION
Formoterol downregulates T cell functions of atopic asthmatics in vitro.
背景
研究了长效β₂受体激动剂福莫特罗对T细胞细胞因子合成的影响。
方法
从特应性哮喘患者中获取人外周血单个核细胞，并用粉尘螨提取物进行刺激。在一些培养物开始时加入不同浓度的福莫特罗。分析细胞因子产生和细胞增殖情况。
结果
福莫特罗以剂量依赖性方式显著抑制变应原诱导的PBMC产生IL-5、IL-13和IFN-γ，而增殖反应未受抑制。
结论
福莫特罗在体外下调特应性哮喘患者的T细胞功能。
Zotero 插件