Chukanov V I, Litvinov V I, Tikhtaev M T, Baenskiĭ A V
Probl Tuberk. 1991(7):57-9.
A method of indirect solid-phase EIA was used to detect serum antibodies in 110 patients with destructive tuberculosis. The preparation with a molecular mass of 38-42 kD isolated from the mycobacteria H37Rv was used as an antigen. Changes in the level of antituberculous antibodies were found during treatment, which are most manifested in 4-6 months of antituberculous therapy and depend on treatment efficiency. The effective therapy is accompanied by a decrease in the level of antituberculous antibodies by that time, while in ineffective therapy it remains high. Hence, changes in the level of antituberculous antibodies may serve as an additional criterion of chemotherapy efficiency.
采用间接固相酶免疫分析法检测110例浸润型肺结核患者血清抗体。以从结核杆菌H37Rv分离出的分子量为38 - 42kD的制剂作为抗原。在治疗过程中发现抗结核抗体水平发生变化，这种变化在抗结核治疗4 - 6个月时最为明显，且取决于治疗效果。有效治疗时，此时抗结核抗体水平会下降，而无效治疗时则仍维持在较高水平。因此，抗结核抗体水平的变化可作为化疗效果的一项附加标准。
