Hausteiner C, Bornschein S, Zilker T, Henningsen P, Förstl H
Department of Psychiatry and Psychotherapy, Technical University of Munich, Germany.
Toxicol Lett. 2007 Jun 15;171(1-2):1-9. doi: 10.1016/j.toxlet.2007.04.010. Epub 2007 May 1.
Idiopathic environmental intolerances (IEI) - formerly multiple chemical sensitivities (MCS) - are characterized by diffuse symptoms reported after exposure to low doses of everyday chemicals. Previous theories about the origin of IEI have emphasized either biological or psychological factors, neglecting a probable interplay. Many have suggested classifying IEI as a somatoform or an anxiety disorder, irrespective of some incongruities. By focusing on dysfunctional cognitions we discuss obvious parallels of IEI with somatoform disorders, and also indicate overlaps with anxiety and delusional disorders. To propose a hypothetical psycho-neurobiological basis of IEI, recent evidence about cortically represented symptoms in the absence of peripheral stimuli is briefly summarized. We conclude that IEI can serve as an illustrative example for the impact of cognitive, representational processes in symptom generation.
特发性环境不耐受（IEI）——以前称为多重化学物质敏感（MCS）——的特征是在接触低剂量日常化学物质后出现弥散性症状。以往关于IEI起源的理论要么强调生物学因素，要么强调心理学因素，而忽略了可能的相互作用。许多人建议将IEI归类为躯体形式障碍或焦虑症，尽管存在一些不一致之处。通过关注功能失调的认知，我们讨论了IEI与躯体形式障碍明显的相似之处，也指出了与焦虑症和妄想症的重叠之处。为了提出IEI的一个假设性心理神经生物学基础，简要总结了近期关于在没有外周刺激情况下皮质表现症状的证据。我们得出结论，IEI可以作为认知、表象过程在症状产生中作用的一个例证。
