Arnold Douglas L
Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University, Montreal, Quebec, Canada.
Neurology. 2007 May 29;68(22 Suppl 3):S83-90; discussion S91-6. doi: 10.1212/01.wnl.0000275237.28259.9d.
MRI is used routinely in clinical practice and pharmaceutical trials to measure disease activity and assess the effects of treatment in multiple sclerosis. Conventional MRI techniques sensitively detect inflammation, demyelination, and tissue injury. Less conventional imaging modalities, such as magnetic resonance spectroscopy and magnetization transfer imaging, and advanced image processing to quantify structural changes can provide more specific and inherently quantitative markers of the pathologic processes underlying the accumulation of disease burden and the progression of clinical disability. Together, these techniques can assess both the anti-inflammatory and the neuroprotective effects of immunomodulatory therapies.
磁共振成像（MRI）在临床实践和药物试验中被常规用于测量疾病活动度，并评估多发性硬化症的治疗效果。传统的MRI技术能够灵敏地检测炎症、脱髓鞘和组织损伤。一些不太常规的成像方式，如磁共振波谱成像和磁化传递成像，以及用于量化结构变化的先进图像处理技术，可以提供更具特异性且本质上为定量的标记物，用于反映疾病负担累积和临床残疾进展背后的病理过程。这些技术共同作用，可以评估免疫调节疗法的抗炎和神经保护作用。
