[预防类固醇性股骨头坏死的基因分析]

[Genetic analysis for prevention of steroid-induced osteonecrosis of the femoral head].

作者信息

Fujioka Mikihiro, Arai Yuji, Kuribayashi Masaaki, Kubo Toshikazu, Nakajima Shigeo

机构信息

Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Department of Orthopaedics.

出版信息

Clin Calcium. 2007 Jun;17(6):894-900.

PMID:17548929

Abstract

Idiopathic osteonecrosis of the femoral head (ION) is caused by disruption of blood flow. This disease often occurs in association with steroid treatment. The pathology of corticosteroid-induced ION is unclear, although abnormalities in the coagulation and fibrinolytic systems or in the lipid metabolism have been reported to be involved. We found the differences of gene polymorphism frequencies of ATP-binding casette, sub-family B, member 1 (ABCB1) C3435T, Apolipoprotein B (ApoB) C7623T and cAMP-response element binding protein-binding protein (CBP) (rs3751845) between ION cases and referent patients among those who were subjected to renal transplantation. For the prediction of ION, it is useful to analyze ABCB1 C3435T, ApoB C7623T and CBP (rs3751845) before the administration of steroids.

摘要

股骨头特发性骨坏死（ION）是由血流中断引起的。这种疾病常与类固醇治疗相关。尽管有报道称凝血和纤维蛋白溶解系统或脂质代谢异常与之有关，但皮质类固醇诱导的ION的病理机制尚不清楚。我们发现，在接受肾移植的患者中，ION病例与对照患者之间，ATP结合盒转运体B家族成员1（ABCB1）C3435T、载脂蛋白B（ApoB）C7623T和环磷酸腺苷反应元件结合蛋白结合蛋白（CBP）（rs3751845）的基因多态性频率存在差异。对于ION的预测，在使用类固醇之前分析ABCB1 C3435T、ApoB C7623T和CBP（rs3751845）是有用的。