Puelles Eduardo
Instituto de Neurociencias de Alicante, CSIC & Universidad Miguel Hernández, 03550 Sant Joan d'Alacant, Spain.
J Neurosci Res. 2007 Dec;85(16):3530-4. doi: 10.1002/jnr.21363.
Recent breakthroughs in the understanding of the genetic program that controls specification of ventral cell fate in the spinal cord and hindbrain have produced useful tools for the study of similar genetic networks in the more complex rostral regions of the central nervous system. Several research groups have elucidated key factors in the potential signaling processes, as well as transcription factors necessary for differentiation of various basal midbrain nuclei. Importantly, there has been substantial progress in understanding the genetic cascade involved in specifying dopaminergic neurons. This knowledge will be crucial in the understanding and possible treatment of Parkinson's disease.
最近在理解控制脊髓和后脑腹侧细胞命运特化的遗传程序方面取得的突破，为研究中枢神经系统更复杂的 Rostral 区域中类似的遗传网络提供了有用的工具。几个研究小组已经阐明了潜在信号传导过程中的关键因素，以及各种基底中脑核分化所需的转录因子。重要的是，在理解参与指定多巴胺能神经元的遗传级联方面已经取得了实质性进展。这些知识对于理解和可能治疗帕金森病至关重要。
