硫酸亚铁七水合物催化的四组分合成保护的高烯丙基胺
FeSO4 x 7H2O-catalyzed four-component synthesis of protected homoallylic amines.
作者信息
Song Qi-Yi, Yang Bai-Ling, Tian Shi-Kai
机构信息
Department of Chemistry, School of Chemistry and Material Science, University of Science and Technology of China, Hefei, Anhui 230026, China.
出版信息
J Org Chem. 2007 Jul 6;72(14):5407-10. doi: 10.1021/jo0704558. Epub 2007 Jun 6.
An efficient catalytic four-component reaction of carbonyl compounds (or acetals/ketals), benzyl chloroformate (CbzCl), 1,1,1,3,3,3-hexamethyldisilazane (HMDS), and allyltrimethylsilane has been successfully developed to produce Cbz-protected homoallylic amines in the presence of 5 mol % of iron(II) sulfate heptahydrate (FeSO4 x 7H2O), an inexpensive and environmentally friendly catalyst, at room temperature.
已成功开发出一种高效的催化四组分反应，该反应涉及羰基化合物（或缩醛/缩酮）、氯甲酸苄酯（CbzCl）、1,1,1,3,3,3-六甲基二硅氮烷（HMDS）和烯丙基三甲基硅烷，在室温下，以5摩尔%的七水合硫酸亚铁（FeSO₄·7H₂O）（一种廉价且环保的催化剂）为催化剂，生成Cbz保护的高烯丙基胺。
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