Hsu Hsiu-cheng, Yang Chih-Hsun, Kuo Tseng-tong, Shih I-Hsin, Hong Hong-Shang
Department of Dermatology, Chang Gung Memorial Hospital, Taipei, Taiwan.
Int J Dermatol. 2007 Jun;46(6):615-8. doi: 10.1111/j.1365-4632.2007.03051.x.
Although an umbilical nodule is common in neonates and young infants, an umbilical nodule of poor therapeutic response will increase the likelihood of other uncommon etiology. Clear cell acanthoma (CCA) has never been described as an oozing umbilical nodule on infants.
To present a case of CCA which occurred on an 8-month-old female infant presenting with one weeping nodule on the umbilicus since early neonate. The lesion underwent skin biopsy and subsequent hematoxylin-eosin and periodic acid-Schiff staining.
Three courses of liquid nitrogen cryosurgery were performed after the diagnosis of CCA was confirmed. The lesion resolved rapidly.
This report presents the first and youngest case of umbilical CCA in the English literature. This case supports the inflammatory dermatosic nature of CCA.
尽管脐部结节在新生儿和幼儿中很常见，但治疗反应不佳的脐部结节会增加其他罕见病因的可能性。透明细胞棘皮瘤（CCA）从未被描述为婴儿脐部有渗出的结节。
报告一例CCA发生于一名8个月大女婴，自新生儿早期起脐部就有一个渗出性结节。对该病变进行了皮肤活检，随后进行苏木精-伊红染色和过碘酸-希夫染色。
确诊CCA后进行了三个疗程的液氮冷冻手术。病变迅速消退。
本报告介绍了英文文献中首例也是最年轻的脐部CCA病例。该病例支持CCA的炎症性皮肤本质。
