包含结构简单的5-炔基-2'-脱氧尿苷的寡脱氧核苷酸对杂交有荧光响应。
Oligodeoxynucleotides incorporating structurally simple 5-alkynyl-2'-deoxyuridines fluorometrically respond to hybridization.
作者信息
Hudson Robert H E, Ghorbani-Choghamarani Arash
机构信息
Department of Chemistry, The University of Western Ontario, London, Ontario, Canada.
出版信息
Org Biomol Chem. 2007 Jun 21;5(12):1845-8. doi: 10.1039/b705805e. Epub 2007 May 16.
DOI:10.1039/b705805e
PMID:17551631
Abstract
Selected 5-ethynyl derivatives of 2'-deoxyuridine are shown to fluorometrically respond to hybridization and selectively base-pair to adenine whilst maintaining duplex stability.
摘要
2'-脱氧尿苷的选定5-乙炔基衍生物显示出对杂交的荧光响应，并能选择性地与腺嘌呤碱基配对，同时保持双链稳定性。
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