Olesen Anne Estrup, Jarvig Line, Hansen Ole Bo, Højsted Jette, Jensen Niels-Henrik, Jonsson Torsten, Sjøgren Per, Sonne Nan Margrethe, Sørensen Jacob Thorsted, Christrup Lona L
Københavns Universitet, Det Farmaceutiske Fakultet.
Ugeskr Laeger. 2007 May 21;169(21):2024-9.
30-40% of cancer patients suffer from pain at diagnosis while 70-80% of patients at progressed stages of the disease suffer from pain. Background pain is treated with long-acting opioids. Breakthrough pain can be treated with shorter acting non-opioid analgesics or opioids. The aim of this study was to describe the medical treatment of pain in cancer patients in connection with six Danish hospital units with special expertise in pain treatment. Differences in the prescription of analgesics were studied. The study was performed as a cross section study of prescribed analgesics. Data was collected by reviewing medical records. The study included 347 patients. A total of 278 patients out of 347 were treated with opioids for background pains. A significant difference was found (P < 0.001) in the frequency of prescribing morphine, oxycodone and fentanyl. For the treatment of background pain secondary analgesics were prescribed for 40% of the patients while 50% of the patients were treated with paracetamol and/or NSAID. According to the medical records 79% of the patients were prescribed analgesics for breakthrough pain. 73% of the 347 patients had strong opioids prescribed for breakthrough pain. For the treatment of background pain opioids were prescribed for the majority of the cancer patients. Morphine and oxycodone were prescribed most frequently. Secondary analgesics and paracetamol and/or NSAID were also prescribed for background pain. The strong opioids were prescribed for the treatment of breakthrough pain. Differences in the prescription of analgesics between the six hospital units were observed in this study.
30%-40%的癌症患者在确诊时遭受疼痛,而70%-80%处于疾病进展期的患者遭受疼痛。背景疼痛用长效阿片类药物治疗。爆发性疼痛可用作用时间较短的非阿片类镇痛药或阿片类药物治疗。本研究的目的是描述丹麦六个在疼痛治疗方面有专业专长的医院单位对癌症患者疼痛的药物治疗情况。研究了镇痛药处方的差异。该研究作为对处方镇痛药的横断面研究进行。通过查阅病历收集数据。该研究纳入了347名患者。347名患者中有278名因背景疼痛接受阿片类药物治疗。在吗啡、羟考酮和芬太尼的处方频率上发现了显著差异(P<0.001)。对于背景疼痛的治疗,40%的患者使用了辅助镇痛药,而50%的患者使用了对乙酰氨基酚和/或非甾体抗炎药。根据病历,79%的患者因爆发性疼痛开具了镇痛药。34%的患者中有73%因爆发性疼痛开具了强效阿片类药物。对于背景疼痛的治疗,大多数癌症患者使用了阿片类药物。吗啡和羟考酮的处方最为频繁。辅助镇痛药以及对乙酰氨基酚和/或非甾体抗炎药也用于背景疼痛的治疗。强效阿片类药物用于治疗爆发性疼痛。本研究观察到六个医院单位之间镇痛药处方的差异。