内侧颞叶癫痫白质的基于体素的全脑形态学测量
Whole-brain voxel-based morphometry of white matter in medial temporal lobe epilepsy.
作者信息
Yu Aihong, Li Kuncheng, Li Lin, Shan Baoci, Wang Yuping, Xue Sufang
机构信息
Department of Radiology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China.
出版信息
Eur J Radiol. 2008 Jan;65(1):86-90. doi: 10.1016/j.ejrad.2007.04.011. Epub 2007 Jun 5.
PURPOSE
The purpose of this study was to analyze whole-brain white matter changes in medial temporal lobe epilepsy (MTLE).
MATERIALS AND METHODS
We studied 23 patients with MTLE and 13 age- and sex-matched healthy control subjects using voxel-based morphometry (VBM) on T1-weighted 3D datasets. The seizure focus was right sided in 11 patients and left sided in 12. The data were collected on a 1.5 T MR system and analyzed by SPM 99 to generate white matter density maps.
RESULTS
Voxel-based morphometry revealed diffusively reduced white matter in MTLE prominently including bilateral frontal lobes, bilateral temporal lobes and corpus callosum. White matter reduction was also found in the bilateral cerebellar hemispheres in the left MTLE group.
CONCLUSION
VBM is a simple and automated approach that is able to identify diffuse whole-brain white matter reduction in MTLE.
目的
本研究旨在分析内侧颞叶癫痫（MTLE）患者全脑白质的变化。
材料与方法
我们对23例MTLE患者和13例年龄及性别匹配的健康对照者进行了研究，使用基于体素的形态学测量（VBM）方法分析T1加权三维数据集。癫痫病灶位于右侧的患者有11例，位于左侧的有12例。数据在1.5T磁共振成像系统上采集，并通过SPM 99软件进行分析以生成白质密度图。
结果
基于体素的形态学测量显示，MTLE患者全脑白质呈弥漫性减少，主要累及双侧额叶、双侧颞叶及胼胝体。左侧MTLE组双侧小脑半球也发现白质减少。
结论
VBM是一种简单且自动化的方法，能够识别MTLE患者全脑弥漫性白质减少。
Zotero 插件