[TRAIL蛋白及mRNA在血管瘤中的表达及意义]

[Expression and significance of TRAIL protein and mRNA in hemangioma].

作者信息

Lin Hui, Chen Shi-Hai, Yin Guo-Qian, Li Dong, Liu Qing-Feng

机构信息

Department of Laser and Plastic Surgery, The First Affiliation Hospital of Guangxi Traditional Chinese Medical University. Nanning 530023, China.

出版信息

Zhonghua Zheng Xing Wai Ke Za Zhi. 2007 Mar;23(2):93-6.

PMID:17554866

Abstract

OBJECTIVE

To detect the expression of TRAIL protein and mRNA in hemangiomas and vascular malformations.

METHODS

Sections of 33 proliferative hemangiomas,28 involuting hemangiomas and 29 vascular malformations were immunostained for TRAIL protein, TRAIL mRNA was examined by in situ hybridization in these tissue.

RESULTS

The TRAIL protein positive rates in proliferative hemangiomas, involuting hemangiomas, vascular malformations and normal skins were respectively 45.45% (15/33), 78.57% (22/28), 0% and 0%. There were significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01). The TRAIL mRNA positive rates were 66.67% (11/33), 89.29 (25/28), 0% and 0% respectively. There were also significant differences among the four pathologies (P < 0.01). The difference between proliferative hemangiomas and involuting hemangiomas was also significant (P < 0.01).

CONCLUSIONS

TRAIL could induce endothelial apoptosis and cause regression of hemangiomas.

摘要

目的

检测TRAIL蛋白和mRNA在血管瘤及血管畸形中的表达。

方法

对33例增殖期血管瘤、28例消退期血管瘤及29例血管畸形组织切片进行TRAIL蛋白免疫染色，采用原位杂交法检测这些组织中的TRAIL mRNA。

结果

增殖期血管瘤、消退期血管瘤、血管畸形及正常皮肤组织中TRAIL蛋白阳性率分别为45.45%（15/33）、78.57%（22/28）、0%和0%。四种病理组织间差异有统计学意义（P<0.01）。增殖期血管瘤与消退期血管瘤之间差异也有统计学意义（P<0.01）。TRAIL mRNA阳性率分别为66.67%（11/33）、89.29%（25/28）、0%和0%。四种病理组织间差异有统计学意义（P<0.01）。增殖期血管瘤与消退期血管瘤之间差异也有统计学意义（P<0.01）。