Prikryl R
Psychiatrická klinika LF MU a FN, Brno.
Cas Lek Cesk. 2007;146(5):434-7; discussion 438-9.
An increased research interest in the relation between diabetes mellitus and dementia or deterioration of cognitive functions has been recently noticed. The relatively rich scientific literature in this topic shows that diabetes mellitus itself can cause an impairment of cognitive functions regardless patient's age or the fact whether he has type 1 or type 2 diabetes mellitus. Type 1 diabetes mellitus leads to a psychomotor retardation while type 2 diabetes mellitus tends to be associated with impaired storage of new information. The exact mechanism through which diabetes impairs cognition has not been explained sufficiently yet, but several hypothetical mechanisms which might explain the relation between diabetes and impaired cognition have been proposed. To explain the etiopathogenetic mechanisms underlying the relation between diabetes and dementia, further research, especially research focused on process clinical-imaging studies or clinical-pathological studies is necessary. As far as clinical practice is concerned, it is important to bear in mind that prevention, timely diagnosis and optimum treatment of diabetes may help to reduce incidence of dementia or cognitive functions' impairment.
最近人们注意到,对糖尿病与痴呆症或认知功能衰退之间关系的研究兴趣有所增加。关于这一主题的相对丰富的科学文献表明,无论患者年龄大小,也无论其患有1型还是2型糖尿病,糖尿病本身都会导致认知功能受损。1型糖尿病会导致精神运动发育迟缓,而2型糖尿病往往与新信息存储受损有关。糖尿病损害认知的确切机制尚未得到充分解释,但已经提出了几种可能解释糖尿病与认知受损之间关系的假设机制。为了解释糖尿病与痴呆症之间关系的病因发病机制,有必要进行进一步的研究,尤其是侧重于临床影像学研究或临床病理学研究的过程的研究。就临床实践而言,重要的是要记住,糖尿病的预防、及时诊断和最佳治疗可能有助于降低痴呆症或认知功能损害的发生率。