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联合治疗可减少黑猩猩(黑猩猩指名亚种)的自伤行为:一例报告

Combination therapy reduces self-injurious behavior in a chimpanzee (Pan Troglodytes Troglodytes): a case report.

作者信息

Bourgeois Sabrina R, Vazquez Maribel, Brasky Kathleen

机构信息

Department of Comparative Medicine, Southwest National Primate Research Center/Southwest Foundation for Biomedical Research, San Antonio, TX 78245-0549, USA.

出版信息

J Appl Anim Welf Sci. 2007;10(2):123-40. doi: 10.1080/10888700701313454.

Abstract

Self-injurious behavior (SIB) remains a severe and intractable abnormal behavior for nonhuman primates in diverse settings and is a significant concern for veterinarians and behavioral scientists. To date, no single pharmacological, behavioral, social, or environmental intervention method has emerged as a reliable permanent cure for treating SIB in all, or even most, individuals. Implementation and evaluation of a combination therapeutic approach to treating SIB for nonhuman primates is rare. In May 2004, a 25-year-old male chimpanzee with severe SIB (M = 2.09 episodes/day, range = 1-4 episodes/day) underwent intensive behavioral intervention that utilized a combination of techniques. The combination therapy approach entailed the following: (a) pharmacological intervention with a gamma-aminobutyric acid (GABA) analogue to treat suspected HIV-related sensory neuropathic pain, (b) positive reinforcement training, and (c) environmental enrichment, as well as social and environmental modification. The severity of SIB warranted immediate implementation of intensive combination therapy rather than a systematic evaluation of the individual treatment options. The individually tailored, multifaceted combination therapy resulted in the virtual elimination of SIB in this chimpanzee over a 2-year period.

摘要

自伤行为(SIB)对于不同环境中的非人灵长类动物而言,仍然是一种严重且难以处理的异常行为,也是兽医和行为科学家极为关注的问题。迄今为止,尚无单一的药物、行为、社会或环境干预方法能成为治疗所有甚至大多数个体SIB的可靠永久治愈方法。对非人灵长类动物SIB采用联合治疗方法的实施和评估很少见。2004年5月,一只患有严重SIB(平均每天发作2.09次,范围为每天1 - 4次)的25岁雄性黑猩猩接受了强化行为干预,该干预采用了多种技术的组合。联合治疗方法包括:(a)使用γ-氨基丁酸(GABA)类似物进行药物干预,以治疗疑似与HIV相关的感觉神经性疼痛;(b)阳性强化训练;(c)环境丰富化,以及社会和环境改造。SIB的严重程度使得必须立即实施强化联合治疗,而不是对个体治疗方案进行系统评估。这种个性化定制的多方面联合治疗在两年时间内几乎消除了这只黑猩猩的SIB。

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