墨西哥裔美国人的血清瘦素浓度、肥胖及体脂分布

Serum leptin concentration, adiposity, and body fat distribution in Mexican-Americans.

作者信息

Peltz Gerson, Sanderson Maureen, Pérez Adriana, Sexton Ken, Ochoa Casares Dania, Fadden Mary Kay

机构信息

The University of Texas at Brownsville & Texas Southmost College, Brownsville, Texas 78520, USA.

出版信息

Arch Med Res. 2007 Jul;38(5):563-70. doi: 10.1016/j.arcmed.2006.12.009. Epub 2007 Apr 16.

DOI:10.1016/j.arcmed.2006.12.009

PMID:17560464

Abstract

BACKGROUND

Leptin is strongly associated with adiposity and few studies have investigated its role in Mexican-Americans. The aims of this study were to examine the association of serum leptin concentration with adiposity and body fat distribution in Mexican-Americans and to develop a predictive model of serum leptin concentration for this ethnic group.

METHODS

Three hundred fifty-two college students (242 women, 110 men; age 18-30 years) were evaluated in this cross-sectional study. Body fat content was assessed using bioelectrical impedance analysis. Correlation between serum leptin levels and several markers of adiposity and body fat distribution were examined in both men and women. Multiple regression analysis was performed to create the predictive model.

RESULTS

Women had higher serum leptin concentrations than men for the same levels of adiposity. After controlling for gender and body fat, only fat mass (FM) expressed in kg, was significantly correlated with serum leptin concentration in men (partial rho = 0.811, p <0.001), whereas body mass index (BMI), hip circumference (HC), and FM expressed in kg, were significantly correlated with serum leptin concentration in women (partial rho = 0.214, p <0.001; partial rho = 0.201, p <0.01; and partial rho = 0.818, p <0.001, respectively). Percent body fat (PBF) was the only significant predictor of serum leptin concentration among men, explaining 42% of the variance in serum leptin concentration. In addition to PBF, waist circumference (WC) and HC were significant predictors of serum leptin concentration among women explaining 65% of the variance in serum leptin concentration.

CONCLUSIONS

Serum leptin concentration is a function of adiposity as determined by PBF in both Mexican-American men and women. HC and WC are associated with serum leptin concentration in Mexican-American women but not in men. BMI alone should not be used in evaluating the association of serum leptin concentration with body fatness in Mexican-Americans.

摘要

背景

瘦素与肥胖密切相关，而针对墨西哥裔美国人中瘦素作用的研究较少。本研究的目的是探讨墨西哥裔美国人血清瘦素浓度与肥胖及体脂分布之间的关联，并为该种族群体建立血清瘦素浓度的预测模型。

方法

在这项横断面研究中，对352名大学生（242名女性，110名男性；年龄18 - 30岁）进行了评估。使用生物电阻抗分析法评估身体脂肪含量。检测了男性和女性血清瘦素水平与多种肥胖及体脂分布标志物之间的相关性。进行多元回归分析以建立预测模型。

结果

在相同肥胖水平下，女性的血清瘦素浓度高于男性。在控制性别和体脂后，仅以千克表示的脂肪量（FM）与男性血清瘦素浓度显著相关（偏相关系数ρ = 0.811，p <0.001），而体重指数（BMI）、臀围（HC）以及以千克表示的FM与女性血清瘦素浓度显著相关（偏相关系数ρ分别为0.214，p <0.001；ρ = 0.201，p <0.01；以及ρ = 0.818，p <0.001）。体脂百分比（PBF）是男性血清瘦素浓度的唯一显著预测因子，可解释血清瘦素浓度变异的42%。除PBF外，腰围（WC）和HC是女性血清瘦素浓度的显著预测因子，可解释血清瘦素浓度变异的65%。