谷胱甘肽S-转移酶GSTM1和GSTT1基因多态性与石棉沉着病

Glutathione S-transferases GSTM1 and GSTT1 polymorphisms and asbestosis.

作者信息

Franko Alenka, Dodic-Fikfak Metoda, Arnerić Niko, Dolzan Vita

机构信息

Clinical Institute of Occupational Medicine, University Medical Centre, Ljubljana, Slovenia.

出版信息

J Occup Environ Med. 2007 Jun;49(6):667-71. doi: 10.1097/JOM.0b013e318065b855.

DOI:10.1097/JOM.0b013e318065b855

PMID:17563610

Abstract

OBJECTIVE

In a nested case-control study, the authors investigated whether the deletion polymorphism of glutathione S-transferases GSTM1 and GSTT1 represents a risk factor for the development of asbestosis.

METHODS

In total, 262 cases with asbestosis and 265 controls, selected from a cohort of 2080 workers occupationally exposed to asbestos, were genotyped for GSTM1 and GSTT1-null alleles. Cumulative exposure for each subject was available.

RESULTS

Asbestosis was associated with cumulative exposure (odds ratio [OR]=3.21, confidence interval [CI] 2.43-4.23) and GSTT1-null genotype (OR=0.61, CI 0.40-0.94), but not with GSTM1-null genotype (OR=1.01, CI 0.71-1.43). The risk of GSTM1-null and GSTT1-null genotype for asbestosis did not change after adjustment by cumulative exposure, smoking, gender, and age.

CONCLUSIONS

An important finding of this study is that GSTT1 gene deletion might have a protective effect on the development of asbestosis.

摘要

目的

在一项巢式病例对照研究中，作者调查了谷胱甘肽S - 转移酶GSTM1和GSTT1的缺失多态性是否是石棉沉着病发生的危险因素。

方法

从2080名职业性接触石棉的工人队列中选取了262例石棉沉着病患者和265名对照，对其GSTM1和GSTT1无效等位基因进行基因分型。每位受试者的累积暴露量数据可得。

结果

石棉沉着病与累积暴露（优势比[OR]=3.21，置信区间[CI] 2.43 - 4.23）和GSTT1无效基因型（OR=0.61，CI 0.40 - 0.94）相关，但与GSTM1无效基因型无关（OR=1.01，CI 0.71 - 1.43）。在对累积暴露、吸烟、性别和年龄进行调整后，GSTM1无效和GSTT1无效基因型患石棉沉着病的风险没有变化。