果蝇中的抗坏血酸及其在衰老过程中的变化。

Ascorbic acid in Drosophila and changes during aging.

作者信息

Massie H R, Shumway M E, Whitney S J, Sternick S M, Aiello V R

机构信息

Masonic Medical Research Laboratory, Utica, New York 13501.

出版信息

Exp Gerontol. 1991;26(5):487-94. doi: 10.1016/0531-5565(91)90037-m.

DOI:10.1016/0531-5565(91)90037-m

PMID:1756780

Abstract

The ascorbic acid content of Drosophila melanogaster was found to be high in the absence of a dietary source. The amount of ascorbic acid per fly declined with aging in both the Oregon R and Swedish C strains. The median life span at 25 degrees C was 45 days for Swedish C and 59 days for Oregon R. The amount of ascorbic acid in Swedish C flies (0.078 micrograms/fly) was higher than that for Oregon R (0.058 micrograms/fly) for newly emerged flies but the rate of decline with aging was greater for Swedish C than Oregon R. The decline in ascorbic acid content with aging was 70.4% for Swedish C versus 19.9% for Oregon R. A brief cold shock was found to significantly increase the amount of ascorbic acid in Oregon R flies. Feeding the precursor of ascorbic acid synthesis, L-gulonolactone, did not improve the life span. Life-time feeding of ascorbic acid did not improve the life span of either Swedish C or Oregon R flies.

摘要

在没有膳食来源的情况下，发现黑腹果蝇的抗坏血酸含量很高。在俄勒冈R和瑞典C品系中，每只果蝇的抗坏血酸含量都随着衰老而下降。在25摄氏度时，瑞典C品系的中位寿命为45天，俄勒冈R品系为59天。新羽化的瑞典C品系果蝇（0.078微克/只）的抗坏血酸含量高于俄勒冈R品系（0.058微克/只），但瑞典C品系随衰老的下降速率比俄勒冈R品系更大。瑞典C品系抗坏血酸含量随衰老的下降率为70.4%，而俄勒冈R品系为19.9%。发现短暂的冷休克能显著增加俄勒冈R品系果蝇的抗坏血酸含量。喂食抗坏血酸合成前体L-古洛糖酸内酯并不能延长寿命。终生喂食抗坏血酸对瑞典C品系或俄勒冈R品系果蝇的寿命均无改善作用。