对促甲状腺素具有高亲和力的甲状腺神经节苷脂：在甲状腺调节中的潜在作用。
Thyroid gangliosides with high affinity for thyrotropin: potential role in thyroid regulation.
作者信息
Mullin B R, Pacuszka T, Lee G, Kohn L D, Brady R O, Fishman P H
机构信息
Laboratory of Biochemical Pharmacology, National Institute of Arthritis, Metabolism, and Digestive Diseases, Bethesda, MD 20014, USA.
出版信息
Science. 1978 Jan 6;199(4324):77-9. doi: 10.1126/science.199.4324.77.
PMID:17569488
Abstract
Thyroid cell membranes contain a multiplicity of gangliosides, some of which inhibit thyrotropin binding to thyroid membranes. The most potent inhibitor is a ganglioside which is present in only trace amounts and appears to have a novel structure. Thyroid gangliosides may play a role in relaying the hormonal message to the thyroid cell.
摘要
甲状腺细胞膜含有多种神经节苷脂，其中一些能抑制促甲状腺激素与甲状腺膜的结合。最有效的抑制剂是一种仅以痕量存在且似乎具有新结构的神经节苷脂。甲状腺神经节苷脂可能在将激素信息传递给甲状腺细胞的过程中发挥作用。
Zotero 插件