Womelsdorf Thilo, Schoffelen Jan-Mathijs, Oostenveld Robert, Singer Wolf, Desimone Robert, Engel Andreas K, Fries Pascal
F. C. Donders Centre for Cognitive Neuroimaging, Radboud University Nijmegen, 6525 EN Nijmegen, Netherlands.
Science. 2007 Jun 15;316(5831):1609-12. doi: 10.1126/science.1139597.
Brain processing depends on the interactions between neuronal groups. Those interactions are governed by the pattern of anatomical connections and by yet unknown mechanisms that modulate the effective strength of a given connection. We found that the mutual influence among neuronal groups depends on the phase relation between rhythmic activities within the groups. Phase relations supporting interactions between the groups preceded those interactions by a few milliseconds, consistent with a mechanistic role. These effects were specific in time, frequency, and space, and we therefore propose that the pattern of synchronization flexibly determines the pattern of neuronal interactions.
大脑处理过程依赖于神经元群体之间的相互作用。这些相互作用由解剖学连接模式以及调节给定连接有效强度的未知机制所支配。我们发现，神经元群体之间的相互影响取决于各群体内节律性活动之间的相位关系。支持群体间相互作用的相位关系比这些相互作用提前几毫秒出现，这与一种机制性作用相符。这些效应在时间、频率和空间上具有特异性，因此我们提出，同步模式灵活地决定了神经元相互作用的模式。
