Wallace Daniel J, Gotto Jennifer
Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Semin Arthritis Rheum. 2008 Feb;37(4):256-9. doi: 10.1016/j.semarthrit.2007.04.008. Epub 2007 Jun 14.
To present a hypothesis accounting for the differential response of bipolar patients diagnosed with fibromyalgia (FM) to standard therapies, taking into account the markedly statistically significant increase of its prevalence in the syndrome.
All articles relating to the heading bipolar illness AND fibromyalgia as well as bipolar illness AND pain were searched using PubMed and Medline since 1966. The prevalence of bipolar illness in our last 100 FM consultations was reviewed.
Ten percent of our 100 most recent FM consultations included patients with an established diagnosis of bipolar illness. They had little if no response to traditional FM interventions and appeared to have vague and uncertain tender point examinations.
Bipolar illness may be associated with a form of chronic musculoskeletal pain complaints that is not FM. Studies into the role that neurotransmitters play in bipolar patients with complaints of musculoskeletal discomfort deserve further exploration.
考虑到双相情感障碍患者中纤维肌痛（FM）综合征患病率在统计学上显著增加，提出一种假设来解释被诊断为纤维肌痛的双相情感障碍患者对标准疗法的不同反应。
自1966年以来，使用PubMed和Medline搜索了所有与标题“双相情感障碍与纤维肌痛”以及“双相情感障碍与疼痛”相关的文章。回顾了我们最近100次纤维肌痛会诊中双相情感障碍的患病率。
在我们最近的100次纤维肌痛会诊中，10%的患者被确诊为双相情感障碍。他们对传统的纤维肌痛干预措施几乎没有反应，并且压痛点检查结果似乎模糊不清、难以确定。
双相情感障碍可能与一种并非纤维肌痛的慢性肌肉骨骼疼痛主诉形式有关。关于神经递质在有肌肉骨骼不适主诉的双相情感障碍患者中所起作用的研究值得进一步探索。
